319 Bronchial Hyperresponsiveness in Obese Adolescents

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319 Bronchial Hyperresponsiveness in Obese Adolescents

considerably associated with BA severity (R 1⁄4 0.4) and IgE-autoreactivity only in obese asthmatics (R 1⁄4 0.58; P 1⁄4 0.01), which showed raised IgEautoAbs to keratin (11.6 6 2 IU/mL) and collagen III (1.03 6 0.3 IU/mL) in comparison with preobese (6.7 6 1.5 IU/mL, 0.3 6 0.01 IU/mL) and nonobese patients. The levels of total IgE in all groups showed no association with BMI and serum leptine c...

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Asymptomatic bronchial hyperresponsiveness in adolescents and young adults.

The clinical significance of asymptomatic bronchial hyperresponsiveness (BHR) is not well-known. The aim of this study was to explore, in a cross-sectional analysis, the characteristics of adolescent subjects with asymptomatic BHR, as compared to nonhyperresponsive subjects and those with symptomatic BHR. The subjects were selected by date of birth from the register of general practitioners. Th...

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Bronchial hyperresponsiveness to hypertonic saline challenge in children and adolescents.

OBJECTIVE To assess airway hyperresponsiveness to 4.5% hypertonic saline solution in comparison to that obtained through challenge with other bronchoconstriction agents and in relation to patient allergic sensitization. METHODS A cross-sectional, experimental study was conducted, initially involving 85 subjects. After exclusions, the final sample consisted of 62 patients, divided into two gro...

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Bronchial Hyperresponsiveness in Asthma*

Measurement ofnonspecific bronchial hyperresponsiveness remains largely a research tool in asthma, and its usefulness in the assessment and management of asthma is poorly defined. We StUdied the relationship of bronchial hyperresponsiveness to the clinical severity of asthma in 54 asthmatic subjects. In order to find out whether measurement of bronchial hyperresponsiveness could be used to pred...

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Allergen-induced Bronchial Hyperresponsiveness

Bradykinin (BK) is a peptide mediator generated at sites of inflammation and its effects are mediated through constitutively expressed B 2 receptor or through induction of B 1 receptors. We examined the role of these receptors in bronchial hyperresponsiveness (BHR). Brown-Norway rats sensitized with ovalbumin (OA) and Al(OH) 3 intraperitoneally, were exposed 3 wk later to either saline or OA ae...

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ژورنال

عنوان ژورنال: World Allergy Organization Journal

سال: 2012

ISSN: 1939-4551

DOI: 10.1097/01.wox.0000412082.98526.fd